Newsletter

HTA Quarterly Spring 2026

In this edition, we discuss the risks of relying on immature data for survival projections in oncology and the importance of selecting robust models to guide HTA decisions. We also explore key challenges and developments in HTA within the UK and Germany, including the impact of limited clinical evidence on NICE appraisals, with strategies to improve submission outcomes, and recent updates to Germany’s AMNOG dossier requirements, highlighting the evolution to trend-based estimates to better align benefit assessments with statutory health insurance patient populations.

Article

Dangerous projections: How poor survival model choices with immature data can misguide HTA decisions and impact patients

Article

NICE problems: Limited clinical evidence

Article

Framing five-year forecasts with German RWE: Recent changes in G-BA rules of procedure and implications for the use of claims data in German AMNOG dossiers

Heard on the street

“The HTACG estimates that it will initiate around 50 joint clinical assessments (JCAs) of medicines… and for the first time, JCAs of selected high-risk medical devices.”

— EU’s Member State Coordination Group on Health Technology Assessment (HTACG) outlining key strategic priorities for 2026

Source: Health Technology Assessment – 2026 Work Programme adopted

HTA by the numbers

200%

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